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好文推荐:铁稳态与宿主防御
作者:秦 源,贾战生,张颖 来源:转化医学电子杂志 2017-05-08

  【摘 要】铁是多细胞生物和几乎所有微生物所需的重要微量元素. 虽然环境中铁储量丰富,但铁常见化合物是微溶的,生物难以获取. 感染和炎症会破坏铁代谢反馈回路. 哺乳动物体内多种宿主防御机制限制了病原微生物获取铁源,降低了其致病性. 机体内铁水平也调控了宿主防御作用,如巨噬细胞中铁含量调节细胞因子的产生. 本文综述了机体和细胞调控铁代谢保护宿主免受病原微生物感染的作用机制.

  【关键词】铁稳态;感染;宿主;预防

  Iron homeostasis and host defense

  QIN Yuan, JIA Zhan⁃Sheng, ZHANG Ying

  Department of Infectious Disease, Tangdu Hospital, The Fourth Military Medical University, Xi􀆳an 710038, China

  【Abstract】Iron is an important trace element for multicellular organisms and almost all microorganisms. Although iron is rich in the environment, common forms of iron are largely insoluble and therefore poorly absorbed by biological organisms. Accordingly,

  iron metabolism in vertebrates is characterized by the conservation and recycling. Infection and inflammation disrupt the iron metabolism feedback loop. The pathogenic microbes that enter the mam⁃ malian host face a variety of defense mechanisms that limit their

  ability to obtain iron and thereby restrict their pathogenicity. Iron levels also regulate host defense, such as the cytokines production in the regulation of iron content in macrophages. This review sum⁃

  marizes the mechanisms of body and cellular iron regulation in the protection of the host from pathogenic microbial infection.

  【Keywords】iron homeostasis; infection; host defense

  全文链接:http://www.ejotm.com/ch/reader/create_pdf.aspx?file_no=20161207001&flag=&journal_id=zhyxdzzz&year_id=2017